How Fasting & Caloric Restriction Impact Health | Dr. Satchin Panda & Dr. Andrew Huberman
Huberman Lab Clips・10 minutes read
Researchers in Joe Takahashi's lab discovered that caloric restriction, particularly when food was distributed at specific times, led to longer lifespans in rats, with those fed during their active cycle living 20% longer. Biomarkers were unable to predict the longevity benefits of caloric restriction or time-restricted feeding, highlighting the complexity of the relationship between diet and lifespan.
Insights
- Caloric restriction, particularly when combined with time-restricted feeding during the active cycle, significantly extended the lifespan of mice in Joe Takahashi's experiment, showcasing the importance of meal timing in enhancing longevity.
- Contrary to expectations, biomarkers were unable to reliably forecast the longevity advantages of caloric restriction or time-restricted feeding, indicating that the mechanisms behind these benefits may be more complex and multifaceted than previously assumed.
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Recent questions
What experiment did Joe Takahashi's lab conduct?
Caloric restriction experiment on rats.
How did time-restricted feeding affect the experiment?
Considered a factor in the benefits of caloric restriction.
What did Joe Takahashi develop to program food delivery?
Smart case for mice to receive food at specific times.
How did mice fed during nighttime compare to controls?
Mice fed at night lived 35% longer than controls.
Could biomarkers predict the benefits of caloric restriction?
Biomarkers could not predict longevity benefits.
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Summary
00:00
Caloric Restriction Extends Lifespan in Mice
- Joe Takahashi's lab conducted a famous experiment on caloric restriction, published in Science last year.
- Rat experiments showed that reducing calorie intake by 20% or 30% led to longer lifespans.
- Researchers observed that rats given reduced calories in one bolus lived longer than those with constant access to food.
- Time-restricted feeding was considered a factor in the benefits of caloric restriction.
- Joe Takahashi developed a smart case to program food delivery to mice at specific times.
- Mice on a caloric restriction diet with food distributed throughout the day and night lived 10% longer.
- Mice on a caloric restriction diet with food restricted to the active cycle lived 20% longer.
- Mice fed during nighttime with the same calories lived 35% longer than controls.
- Biomarkers could not predict the longevity benefits of caloric restriction or time-restricted feeding.
