REVERSE AGING: What To Eat & When To Eat For LONGEVITY | David Sinclair
Dr Rangan Chatterjee・2 minutes read
Eating less, activating longevity genes, and intermittent fasting can promote health and longevity by triggering hormesis and protecting against aging and disease. Understanding and manipulating pathways like sirtuins, mtor, and ampk through lifestyle practices and supplements can significantly impact aging processes and overall health.
Insights
- Eating less through methods like intermittent fasting activates longevity genes that protect against aging and promote health.
- Longevity genes like sirtuins, mtor, and ampk play crucial roles in controlling aging processes and can be influenced by lifestyle practices and supplements.
- Lifestyle factors such as diet, exercise, and stress management significantly impact health and aging, emphasizing the importance of preventive healthcare.
- Advances in age-reversal technologies, like gene therapy, have the potential to extend human lifespan significantly, with implications for population growth and economic productivity.
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Recent questions
What lifestyle changes can promote longevity?
Lifestyle changes like eating less, consuming the right foods, moderate exercise, quitting smoking, and limiting alcohol intake can promote longevity. These adjustments can activate longevity genes like sirtuins, mtor, and ampk, which protect against DNA damage and aging. By focusing on root causes like chronic inflammation and insulin resistance, many diseases can be improved, rather than treating them as separate conditions. Additionally, incorporating high-intensity exercise for short durations, like 10 minutes several times a week, can provide long-term health benefits. Overall, adopting a healthy lifestyle early on, such as in the late 20s and 30s, can help slow down the aging process and improve overall health and longevity.
How can intermittent fasting impact health?
Intermittent fasting, time-restricted eating, and skipping meals all essentially mean eating less often to promote health and longevity. By eating less, such as through caloric restriction or intermittent fasting, longevity genes like sirtuins, mtor, and ampk are activated, protecting against DNA damage and promoting health. Research shows that animals on restricted eating schedules live longer and healthier lives, emphasizing the benefits of intermittent fasting. Gradually easing into intermittent fasting is crucial to avoid overwhelming the body and ensure long-term success. By understanding and manipulating longevity pathways through practices like intermittent fasting, individuals can significantly impact their health and longevity.
What role does metformin play in longevity?
Metformin is a drug that boosts AMPK activity and is commonly used for type 2 diabetes, but some people take it for longevity and have lower risks of diseases like cancer and heart disease. Metformin's role in delaying aging is discussed, highlighting its impact on insulin sensitivity and mitochondrial function, potentially influencing the gut microbiome. By focusing on root causes like chronic inflammation and insulin resistance, many diseases can be improved, rather than treating them as separate conditions. Metformin, when used in conjunction with lifestyle changes and other supplements, can contribute to promoting longevity and overall health.
How can biological age be monitored?
Biological age can be monitored through advanced technology, like stick-on patches and mouth swabs, providing valuable feedback for individuals to make lifestyle changes and potentially reverse aging. Regular monitoring of blood biomarkers and DNA methylation patterns can help determine biological age and guide interventions to slow down or reverse aging. By understanding and manipulating longevity pathways through practices like intermittent fasting and exercise, individuals can significantly impact their health and longevity. The epigenome, which controls gene expression, can be influenced by lifestyle factors like exercise and fasting, impacting the aging process.
What are the benefits of activating longevity genes?
Activating longevity genes like sirtuins, mtor, and ampk through practices like intermittent fasting can protect against DNA damage, promote health, and improve longevity. These genes are survival mechanisms that protect against aging and disease, even though evolution doesn't prioritize longevity. By understanding and manipulating these pathways, individuals can significantly impact their health and longevity. Lifestyle practices like eating less, exercising, and taking supplements can influence these longevity pathways, leading to improved overall health and potentially reversing the aging process.
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