Pharmacology - PHARMACOKINETICS (MADE EASY)
Speed Pharmacology・9 minutes read
Pharmacokinetics is vital for understanding drug action through absorption, distribution, metabolism, and elimination, with factors like pH and blood flow influencing drug absorption rates and bioavailability important for comparing drug formulations. Drug distribution, predicted by volume of distribution, depends on factors like lipophilicity and binding to plasma proteins, while drug elimination routes, like hepatic and renal routes, impact drug duration of action and steady state concentrations.
Insights
- Understanding pharmacokinetics involves absorption, distribution, metabolism, and elimination of drugs, which are crucial for drug action.
- Factors such as pH, surface area, and blood flow impact drug absorption rates, while bioavailability is key for comparing different drug formulations and administration routes.
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Recent questions
What does pharmacokinetics focus on?
Drug action through absorption, distribution, metabolism, and elimination.
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Summary
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Understanding Pharmacokinetics: Absorption, Distribution, Elimination, Bioavailability
- Pharmacokinetics is crucial to understanding drug action, focusing on absorption, distribution, metabolism, and elimination.
- Absorption of drugs can occur through passive diffusion, facilitated diffusion, active transport, or endocytosis.
- Factors affecting drug absorption include pH, surface area, and blood flow, leading to variable absorption rates.
- Bioavailability is the ratio of oral drug AUC to IV drug AUC, crucial for comparing drug formulations and routes of administration.
- Distribution of drugs depends on factors like lipophilicity, blood flow, capillary permeability, and binding to plasma proteins and tissues.
- Volume of distribution predicts drug concentration in blood or tissues, guiding drug dosing decisions.
- Drug elimination involves hepatic, renal, and biliary routes, with most drugs following first-order kinetics.
- Half-life and steady state concentrations are essential in determining drug duration of action and therapeutic effectiveness.
