Pharmacokinetics: Absorption, Distribution, Metabolism, Excretion - Pharmacology Basics |@LevelUpRN
Level Up RN・4 minutes read
Pharmacokinetics includes absorption, distribution, metabolism, and excretion, each influenced by various factors impacting how medications work in the body. Metabolism, primarily in the liver, is affected by multiple factors such as age, genetics, and environmental factors, leading to the need for alternative routes for some medications.
Insights
- Absorption of medications is influenced by solubility, dose, formulation, and pH levels, determining the speed at which drugs enter the bloodstream.
- Metabolism primarily takes place in the liver and is affected by various factors like liver function, age, genetics, sex, hormones, and environmental elements, leading to the need for alternative routes for certain medications due to the first-pass effect.
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Summary
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Understanding Pharmacokinetics: Absorption, Distribution, Metabolism, Excretion
- Pharmacokinetics involves four phases: absorption, distribution, metabolism, and excretion.
- Absorption is influenced by factors like solubility, dose, formulation, and pH levels, affecting how quickly a medication enters the bloodstream.
- Distribution relies on factors such as plasma protein binding, permeability at the destination site, and circulation, impacting how medications reach their intended site of action.
- Metabolism occurs mainly in the liver, affected by liver function, age, genetics, sex, hormones, and environmental factors, with some medications requiring alternative routes due to the first-pass effect.
