Pharmacokinetics MADE EASY FOR BEGINNERS
The Pharmacist Academy・2 minutes read
Pharmacokinetics studies drug movement in the body through absorption, distribution, metabolism, and elimination, with factors like bioavailability, distribution, and volume of distribution playing key roles. Drug absorption methods include passive diffusion, facilitated diffusion, active diffusion, and endocytosis, while drug distribution involves transport from the bloodstream to tissues influenced by drug properties and blood flow.
Insights
- Pharmacokinetics studies how drugs move in the body, including absorption, distribution, metabolism, and elimination, each influenced by factors like drug properties and physiological conditions.
- Bioavailability measures the amount of drug reaching the bloodstream, with IV administration providing full bioavailability, while metabolism and elimination are vital processes that determine drug efficacy and safety, affected by renal function and drug characteristics.
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Recent questions
What is pharmacokinetics?
The study of how drugs move through the body.
How does drug absorption occur?
Drug absorption occurs through various mechanisms like passive diffusion, facilitated diffusion, active diffusion, and endocytosis, influenced by factors such as lipophilicity, size, and charge.
What is bioavailability?
Bioavailability refers to the amount of drug absorbed that reaches the bloodstream, with IV administration providing 100% bioavailability.
What does drug distribution involve?
Drug distribution involves delivering the drug from the bloodstream to body tissues, influenced by drug properties, blood flow, and the pH of the site of action.
What is drug metabolism and elimination?
Drug metabolism involves the breakdown of drugs, while elimination focuses on removing drugs and metabolites from the body through routes like the kidneys and biliary system, influenced by factors like drug size, polarity, and renal health.
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Summary
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Drug Movement Through Body: Pharmacokinetics Essentials
- Pharmacokinetics is the study of how drugs move through the body, involving absorption, distribution, metabolism, and elimination.
- Drug absorption occurs through passive diffusion, facilitated diffusion, active diffusion, and endocytosis, with factors like lipophilicity, size, and charge affecting the process.
- Bioavailability refers to the amount of drug absorbed that reaches the bloodstream, with IV administration providing 100% bioavailability.
- Distribution involves delivering the drug from the bloodstream to body tissues, influenced by drug properties, blood flow, and the pH of the site of action.
- The volume of distribution indicates how a drug distributes between plasma and tissues, impacting dosing requirements.
- Metabolism and elimination are crucial pharmacokinetic parameters, with metabolism involving the breakdown of drugs and elimination focusing on removing drugs and metabolites from the body.
- Elimination can occur through various routes, primarily via the kidneys and biliary system, with factors like drug size, polarity, and renal health affecting the process.
