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Harvard Professor REVEALS How To SLOW & REVERSE AGING | Dr. David Sinclair

Tom Bilyeu・47 minutes read

David Sinclair's research on aging delves into a DNA clock that predicts lifespan, emphasizing the importance of factors like the epigenome and sirtuins in promoting longevity. Recommendations for enhancing health and longevity include strategies like intermittent fasting and the use of supplements like metformin and resveratrol to potentially reset the biological clock and improve overall well-being.

Insights

DNA clock determines biological age and predicts mortality, with interventions like metformin and NAD precursors potentially resetting aging processes through gene expression changes and improved cellular function.
Stressing the body positively with activities like exercise and fasting, activating enzymes like sirtuins, can enhance longevity and health by mimicking beneficial stress responses, ultimately impacting gene expression and cellular repair systems crucial for extending lifespan.

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Summary

00:00

"Unlocking Longevity: DNA Clocks and Sirtuins"

Level three of aging involves a DNA clock that determines our biological age and can predict when we might die.
David Sinclair, a Harvard professor, is renowned for his work on human longevity and his book "Lifespan" challenges conventional views on aging and mortality.
Aging is characterized by eight hallmarks, including telomere attrition and mitochondrial decline, but understanding the upstream cause is crucial.
The epigenome, distinct from genetics, controls gene expression by regulating which genes are turned on or off.
The epigenome's analog nature allows for dynamic changes in gene expression based on cellular needs and environmental factors.
Proteins in the cell, like enzymes, play a crucial role in DNA repair, gene silencing, and maintaining cellular function.
Sirtuins, a type of enzyme, respond to cellular conditions and can be activated through factors like exercise and fasting to promote longevity.
Stressing the body through activities like running and intermittent fasting can activate sirtuins and enhance cellular health.
Hormesis, the concept that mild stress can be beneficial, suggests that controlled stressors like exercise and fasting can improve health.
Pulsing stressors like intermittent fasting, rather than chronic calorie restriction, may offer similar longevity benefits without the negative effects of constant deprivation.

13:52

"Extending Lifespan: Evolution, Metformin, and Cryotherapy"

Aging is primarily due to complacent repair systems, leading to a decline in natural selection after 40.
Species live as long as needed to reproduce, with some exceptions like whales living longer due to fewer predators.
Humans were not apex predators until recently, impacting lifespan; now, we have a longer life expectancy.
Evolution could potentially lead to humans evolving to live up to 200 years.
Resetting the biological clock involves three levels: changing gene expression, silencing genes, and DNA methylation.
DNA methylation can predict biological age and potential lifespan based on chemical modifications.
Metformin activates the AMPK pathway, mimicking hunger and improving insulin sensitivity.
Metformin's slight poisoning effect leads to increased mitochondria and insulin sensitivity.
Metformin should be cycled with exercise to avoid blunting exercise effects on mitochondria.
Cold exposure, like cryotherapy, can build brown fat, boost metabolism, and potentially aid in weight management.

28:02

"Rejuvenation through Heat and Cellular Reprogramming"

Subject spends an hour on Sundays in various heat treatments.
Initial treatment involves 15 minutes at 150 degrees Fahrenheit.
Proceeds to a steam room with lower temperatures due to high humidity.
Enjoys the feeling of being in the steam room for skin health.
Concludes with a hot tub session followed by immersion in water below 4 degrees Celsius.
Recent work involves tweaking cells and tissues of mice to reset aging clock.
By disturbing proteins through DNA cutting, survival circuits are disrupted.
Results in accelerated aging in mice based on histology and molecular clock.
Shinya Yamanaka's work on reversing aging clock in cells using specific genes.
Resetting age in various species, including dogs, cats, sheep, and monkeys.
Potential implications for human rejuvenation and healing through cellular reprogramming.
Testing on mice with an NAD booster molecule shows improved physical performance.
NAD precursors include NR and NMN, raising energy levels in older individuals.
Author's father's positive experience with NMN supplementation for rejuvenation.
Resveratrol's initial promise in mimicking caloric restriction for health benefits.
Scientific and corporate controversies surrounding resveratrol's efficacy.
Research confirming resveratrol's binding to cellular enzymes for health benefits.
Creation of a mutant mouse resistant to resveratrol's effects on cellular enzymes.

41:50

"Longevity through Resveratrol, Fasting, and Monitoring"

Resveratrol is taken as a supplement, commercially available and should be 98% pure, with a recommended daily intake of roughly a gram, typically mixed into yogurt.
Monitoring health through blood tests is crucial, with a suggestion to use a service like Inside Tracker to analyze around 30 blood parameters, aiding in understanding the impact of lifestyle changes, supplements, or medications.
To enhance longevity and health, a key recommendation is intermittent fasting, skipping a meal to avoid overeating and triggering defensive bodily responses, potentially contributing to maintaining health until advanced medical interventions are available.
David Sinclair, a prominent figure in longevity research, advocates for understanding the aging process to extend human lifespan, emphasizing the importance of making impactful changes in health habits, such as intermittent fasting, to improve overall well-being.

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