Why fentanyl withdrawal is so unbearable

STAT2 minutes read

Opioid withdrawal can be fatal due to dehydration from symptoms like diarrhea and vomiting, with initial pleasurable effects leading to dependence as the body becomes reliant on opioids. Withdrawal from short-acting opioids can cause intense cravings, flu-like symptoms, and mental distress, with stigma around medications like methadone and buprenorphine stemming from a misunderstanding between physical dependence and addiction.

Insights

  • Opioid withdrawal can be life-threatening due to severe dehydration from symptoms like diarrhea and vomiting, emphasizing the critical need for medical intervention and support during this process.
  • The distinction between physical dependence and addiction is crucial in understanding opioid use disorder treatment, with medications like methadone and buprenorphine aiming to maintain physical dependence to prevent overdose and enable normal daily functioning, challenging common misconceptions and stigma surrounding these treatments.

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Recent questions

  • What are the dangers of opioid withdrawal?

    Opioid withdrawal can be dangerous as it can lead to death due to severe dehydration from symptoms like diarrhea and vomiting. It is crucial to seek medical help when experiencing withdrawal symptoms to prevent any life-threatening complications.

  • How do opioids affect the body?

    Opioids bind to brain receptors, blocking pain signals, increasing feel-good hormones like dopamine and serotonin, and reducing stress responses. Initially, they provide pleasurable effects such as calmness, euphoria, and pain relief, but the body quickly becomes dependent on them.

  • What are the symptoms of opioid withdrawal?

    Withdrawal from short-acting opioids like heroin or fentanyl can start within 8-12 hours, peak at 2-3 days, and last up to 10 days. Symptoms include intense cravings, restlessness, flu-like symptoms, and severe physical and mental distress. Seeking medical assistance is crucial to manage these symptoms effectively.

  • Why is there stigma around medications for opioid use disorder?

    Stigma around medications like methadone and buprenorphine for opioid use disorder stems from a misunderstanding between physical dependence and addiction. The best treatments aim to maintain physical dependence to prevent overdose and allow normal functioning, but this distinction is often misconstrued, leading to stigma.

  • How can opioid dependence be managed effectively?

    Opioid dependence can be managed effectively through medications like methadone and buprenorphine, which help maintain physical dependence to prevent overdose and allow individuals to function normally. Seeking professional help and following a treatment plan tailored to individual needs is crucial for successful management of opioid dependence.

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Summary

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Opioid withdrawal: dangers, symptoms, and treatments

  • Opioid withdrawal can lead to death due to severe dehydration from symptoms like diarrhea and vomiting.
  • Initially, using opioids provides pleasurable effects such as calmness, euphoria, and pain relief, but the body quickly becomes dependent on them.
  • Opioids bind to brain receptors, blocking pain signals, increasing feel-good hormones like dopamine and serotonin, and reducing stress responses.
  • Withdrawal from short-acting opioids like heroin or fentanyl can start within 8-12 hours, peak at 2-3 days, and last up to 10 days, causing intense cravings, restlessness, flu-like symptoms, and severe physical and mental distress.
  • Stigma around medications like methadone and buprenorphine for opioid use disorder stems from a misunderstanding between physical dependence and addiction, with the best treatments maintaining physical dependence to prevent overdose and allow normal functioning.
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