RNA interference (RNAi): by Nature Video
nature video・2 minutes read
RNA interference plays a vital role in gene regulation through small interfering RNAs (siRNAs) and microRNAs (miRNAs) guiding the RNA-induced silencing complex (RISC) to degrade or inhibit specific messenger RNAs. SiRNAs with perfect complementarity cleave their targets, while miRNAs with imprecise matching can impact multiple messenger RNAs, influencing various biological processes.
Insights
- siRNAs have perfect complementarity to their target messenger RNAs, allowing for precise cleavage by Argonaut proteins within RISC.
- miRNAs, with imprecise matching to target messenger RNAs, can impact multiple biological processes in diverse organisms due to their ability to target numerous mRNA sequences.
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Recent questions
What is RNA interference?
A mechanism in gene regulation involving siRNAs and miRNAs.
What are siRNAs and miRNAs?
Small RNA molecules involved in gene regulation.
How do siRNAs function?
By cleaving target messenger RNAs with perfect complementarity.
What is the role of miRNAs in gene regulation?
Targeting numerous messenger RNAs with imprecise matching.
How does RNA interference impact gene expression?
By guiding RISC to degrade or inhibit translation of specific messenger RNAs.
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Summary
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RNA Interference: Gene Regulation Mechanism Explained
- RNA interference (RNAi) is a crucial mechanism in gene regulation, involving small interfering RNAs (siRNAs) and microRNAs (miRNAs) that guide the RNA-induced silencing complex (RISC) to target specific messenger RNAs for degradation or inhibition of translation.
- siRNAs, approximately 21 nucleotides long, have perfect complementarity to their target messenger RNAs, leading to cleavage by Argonaut proteins within RISC, while miRNAs, with imprecise matching, can target numerous messenger RNAs, influencing various biological processes across different organisms.
