Part I - Inflammation
Armando Hasudungan・6 minutes read
Inflammation is the body's response to harmful stimuli, involving various cells and mediators to initiate defense and repair. Macrophages play a crucial role in secreting cytokines during inflammation, leading to local effects like tissue repair and systemic effects like fever and leukocytosis.
Insights
- Inflammation is the body's defense mechanism against harmful stimuli, involving various cells and mediators like plasma inflammatory proteins and histamine from mast cells, aiming to repair and protect the affected area.
- Macrophages play a crucial role during inflammation by secreting cytokines like TNF alpha and interleukin 1, leading to local effects such as inflammation and tissue repair, as well as systemic effects like fever and leukocytosis, promoting the migration of immune cells to the inflamed tissue.
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Recent questions
What is the purpose of inflammation in the body?
Inflammation is the body's response to harmful stimuli, aiming to bring defense and immune cells to the affected area, inactivate invaders, and initiate repair. It is clinically denoted by the suffix "itis," such as dermatitis or arthritis.
What are the key cells and mediators involved in inflammation?
Inflammation involves various cells and mediators, including plasma inflammatory mediators like kabbala proteins and kinases, and cell-derived inflammatory mediators like histamine from mast cells. Other cells involved are phagocytes, tissue macrophages, and dendritic cells like Langerhans cells.
How do pathogens trigger responses during an injury?
During an injury, pathogens trigger responses by cells like mast cells and macrophages, leading to histamine release causing vasodilation and increased vascular permeability. This allows immune cells to migrate to the inflamed area, a process known as diapedesis.
What are the effects of cytokines secreted by macrophages during inflammation?
Macrophages secrete cytokines like TNF alpha and interleukin 1, causing local effects like inflammation and tissue repair by stimulating fibroblasts. Systemic effects include fever and leukocytosis, promoting the migration of immune cells like neutrophils and monocytes into the inflamed tissue.
How does inflammation promote the migration of immune cells to the affected area?
Inflammation promotes the migration of immune cells to the affected area by triggering responses from cells like mast cells and macrophages, leading to histamine release causing vasodilation and increased vascular permeability. This allows immune cells to migrate to the inflamed area, a process known as diapedesis.
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Summary
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Understanding Inflammation: Body's Defense Mechanism and Response
- Inflammation is the body's response to harmful stimuli, aiming to bring defense and immune cells to the affected area, inactivate invaders, and initiate repair. It is clinically denoted by the suffix "itis," such as dermatitis or arthritis.
- Inflammation involves various cells and mediators, including plasma inflammatory mediators like kabbala proteins and kinases, and cell-derived inflammatory mediators like histamine from mast cells. Other cells involved are phagocytes, tissue macrophages, and dendritic cells like Langerhans cells.
- During an injury, pathogens trigger responses by cells like mast cells and macrophages, leading to histamine release causing vasodilation and increased vascular permeability. This allows immune cells to migrate to the inflamed area, a process known as diapedesis.
- Macrophages secrete cytokines like TNF alpha and interleukin 1, causing local effects like inflammation and tissue repair by stimulating fibroblasts. Systemic effects include fever and leukocytosis, promoting the migration of immune cells like neutrophils and monocytes into the inflamed tissue.
