25. Cancer 1
MIT OpenCourseWare・2 minutes read
Cell division and tissue regeneration are regulated differently, leading to diseases like cancer due to mutations affecting normal cell behavior. Key players in the cell cycle pathway include Rb, growth inhibitors, E2F, G1 cyclin, CDK, with Rb as a tumor suppressor gene linked to retinoblastoma. Understanding the inheritance and mechanisms of cancer at the cellular and tissue level is crucial for assessing cancer risk and developing targeted treatments, like Gleevec for chronic myelogenous leukemia.
Insights
- Mutations in oncogenes promote uncontrolled cell growth, while tumor suppressor genes inhibit growth, maintaining cellular stability and preventing cancer development.
- Understanding the genetic basis of diseases like retinoblastoma and colon cancer is essential for assessing cancer risk and developing targeted treatments that can effectively inhibit specific pathways involved in tumorigenesis.
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Recent questions
What are oncogenes and tumor suppressor genes?
Oncogenes promote cell growth, while tumor suppressor genes inhibit uncontrolled division.
How does the G1 to S transition regulate cell division?
The G1 to S transition is controlled by key regulators like the G1 cyclin and transcription factor E2F.
What is retinoblastoma and how does it manifest?
Retinoblastoma is a rare childhood eye tumor originating from retinal tissue.
How does loss of heterozygosity contribute to cancer development?
Loss of heterozygosity can occur through various mechanisms, promoting cancer progression.
What is the role of APC gene in colon cancer development?
The APC gene functions as a brake on Wnt signaling, regulating cell behavior in the colon.
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